Browse current Small Business Innovation Research and Small Business Technology Transfer opportunities.
The purpose of this topic area is to catalyze the development of a universal, “plug-and-play” synthetic biology platform that enables next-generation microbial chassis capable of performing a broad array of programmable functions. While this soli
Development of an annual test to inform women about their future fertility - The purpose of this topic is to discover new biomarkers that provide women with actionable data for fertility planning. Results from this work will help inform the program m
The purpose of this topic aims to develop treatments for endometriosis that are non-surgical. Proposers are expected to develop novel, non-surgical therapies to decrease the size or deactivate endometrial implants, to decrease inflammation cause by i
he purpose of this topic supports the advancement, commercialization, and translation of technologies that originated from ARPA-H funded efforts. It is intended to help small businesses and startups develop viable products based on these technologies
The purpose of this topic is to spur the development of novel, rapid diagnostic assays for multi-system autoimmune disease, which represents an unmet healthcare need. Moreover, in its ideal embodiment this diagnostic test might allow typical primary
About 9,550 children in the United States under the age of 15 will be diagnosed with cancer in 2025 (https://www.cancer.org/cancer/cancer-in-children/key-statistics.html). Cancer is the leading cause of death from disease in children ages 1 to 14 in
About 9,550 children in the United States under the age of 15 will be diagnosed with cancer in 2025 (https://www.cancer.org/cancer/cancer-in-children/key-statistics.html). Cancer is the leading cause of death from disease in children ages 1 to 14 in
This topic seeks to design and develop an SDR featuring multi-band operation, advanced frequency management, and enhanced processing capabilities. The program desires to create drop-in, or near drop-in replacements of existing radio systems to enhanc
The purpose of this topic is to develop next-generation bioadhesive platforms that can safely and reliably seal, bond, and repair a wide range of tissues in challenging clinical conditions, including wet, bloody, and mechanically dynamic environments
The purpose of this topic aims to take a first step toward AI-assisted intracranial microsurgery by creating a high-resolution, physically and anatomically accurate virtual human brain. Site Map Privacy Policy Report Fraud, Waste & Abuse Open Governm
This Department of the Air Force (DAF) focused open topic seeks C-sUAS defeat options for transition into the USAF and USSF, with a specific focus on transitioning technologies to AFLCMC/ES and the Joint Interagency Task Force 401 (JIATF 401) marketp
The Office of Technology, Transition and Commercial Partnerships (T3CP) is seeking innovative approaches that accelerate the commercialization and dual-use transition of government funded intellectual property made available through the T3CP Patent H
The Department of War (DoW) is pivotally shifting toward "affordable mass" to counter peer adversaries who are rapidly expanding their military capabilities. While hypersonic systems offer high speeds, their exorbitant costs—exceeding $50 million p
This topic seeks to rapidly field non–missile-warning, space and/or ground enabled sensing and analytic capabilities that enhance warfighter decision speed. Space Force Components and Combatant Commands increasingly depend on commercially deri
Adaptive optics (AO), with wavefront sensors and deformable mirrors based on spatial light modulators (SLMs) has been used for active laser beam control and propagation path compensation. The liquid crystal on silicon (LCoS) is the most mature techno
Current thermal-imaging systems rely heavily on digital post-processing to perform feature extraction and image processing, increasing latency, power consumption and system complexity. Recent advances in nonlocal metasurfaces have demonstrated analog
Modern warfare has increased the demand for low-cost, attritable unmanned drone vehicles. Examples of such platforms used worldwide are the Shahed 136 and the LUCAS. Thermal cameras give these platforms the ability to operate at night and under adver
Rayon-based carbon fibers remain the choice of material as reinforcement in carbon phenolic composites used as thermal protection systems for hypersonics. Currently, rayon fiber precursors used to make rayon-based carbon fibers are not produced in th
By integrating the contextualization power of LLMs with the statistical power of ML, the program aims to leverage the benefits of both to provide domain-specific statistical contextualization of structured data. This effort must: • Survey and resea
All U.S. Army COMPOs face a technical problem concerning the ability to augment the MEDEVAC fleet to reach the end strength goal of 446 MEDEVAC aircraft. The capability gap is driven by the reduction of the HH-60M fleet numbers, cancellation of the U
Develop and integrate distributed Artificial Intelligence (AI) technology that can collaboratively control a multi-agent Group 1 or Group 2 Unmanned Aerial System (UAS) swarm to defend an area against a numerically superior attacking enemy swarm. The
The Missile Defense Agency (MDA) seeks to leverage neuromorphic technology to maximize performance and efficiency for terrestrial and space applications. Neuromorphic processing supports multiple applications that advance the Missile Defense System,
The proposed initiative focuses on the development of event-based sensing technology that utilizes advanced neural network models to enhance the navigation capabilities of kill vehicles and satellites. This system aims to operate independently of GNS
The use of RF cables has difficulty meeting environmental conditions while maintaining signal integrity and power requirements. Hypersonic surface temperatures can exceed over 1,000-degree C. Waveguides provide high power transmission and might be ea
This topic seeks development of a flight antenna capable of multiple node, simultaneous, high-speed, secure communication in meshed High Assurance Internet Protocol Encryptors (HAIPE) "Zero Trust" platforms and networks. System shall provide wideband
The performance and survivability of Department of War (DoW) and space systems, especially those operating in space environments, are critically affected by radiation. Radiation testing of parts is a major cost and schedule driver for DoW and space s
Single-photon counting and timing achieves light detection at the fundamental quantum limit, unlocking next generation capabilities in quantum imaging and environmental sensing. Many applications require counting/timing photons at very high rates (>G
DARPA seeks to enable high performance computing for DoW systems that must function in extreme environments. Nonvolatile memory is a bottleneck, even in commercial High-Performance Computing and Artificial Intelligence systems. This phenomenon is ref
As launch cadences and mission tempos continue to increase, this topic seeks to modernize operational processes to maintain high levels of mission readiness. The goal is to improve efficiency and enhance access to institutional knowledge to better su
The DoW needs quantum sensing capabilities that are Size, Weight, and Power (SWaP) compatible with a broad range of vehicles and platforms, and it seeks to develop commercial, off-the-shelf (COTS) components with integrated capabilities that currentl
Quantum communication systems, quantum-enhanced LiDAR, and quantum sensing platforms share a critical and unmet instrumentation need: a spectrometer capable of simultaneously achieving large étendue (high optical throughput) and high spectral resolu
Modern radar operations face unprecedented challenges in increasingly congested and contested environments. Traditional radar systems rely on fixed or pre-programmed waveform libraries, making their transmissions highly predictable and susceptible to
As a part of this feasibility study, the proposers shall address all viable system design options with respective specifications. This capability will integrate AI-enabled multi-agent planning and adversarial reasoning into a software system that sup
Develop and integrate distributed Artificial Intelligence (AI) technology that can collaboratively control a multi-agent Group 1 or Group 2 Unmanned Aerial System (UAS) swarm to defend an area against a numerically superior attacking enemy swarm. The
The Missile Defense Agency seeks advancing and incorporating quantum and photonic technologies that can augment current state-of-the-art radar and communication systems into fielded hardware. Photonic technologies coupled with measurable quantum effe
Modern military operations across air, land, and sea domains increasingly rely on heterogeneous teams of unmanned platforms tasked with detecting, identifying, and disambiguating targets at long range, often under appearance ambiguity, viewpoint and
Single-photon counting and timing achieves light detection at the fundamental quantum limit, unlocking next generation capabilities in quantum imaging and environmental sensing. Many applications require counting/timing photons at very high rates (>G
The performance and survivability of Department of War (DoW) and space systems, especially those operating in space environments, are critically affected by radiation. Radiation testing of parts are major cost and schedule drivers for DoW and space s
The frontier of predictive AI is running into a data wall: the high-quality open text that has powered recent models is largely exhausted, and the two ways around it both have ceilings. Reusing existing data yields little after a few passes, and synt
USSOCOM seeks a field-deployable capability to enable detection, discrimination, and triangulation of dangerous or restricted materials without direct sampling, physical breach, or active signal emission. As a part of this feasibility study, the prop
Solid propellant propulsion systems which utilize multiple pulses commonly use separate pyrotechnic or pyrogen igniters for each pulse. In recent years, alternative ignition methods have been conceptualized which could ignite rocket motors multiple t
Current thermal battery technologies, while highly reliable for critical power applications in missile defense, present limitations that directly impact the performance and capabilities of advanced interceptor systems. Key constraints include their s
The Missile Defense Agency (MDA) seeks to add multiple resilient layers to the Missile Defense System. The proposed system uses current power infrastructure to detect potential anomalies generated by unknown sources. Site Map Privacy Policy Report Fr
Background The Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs (also known as America's Seed Fund) are major sources of early-stage funding for U.S. technology development and commercialization. NIH SB
Background The Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs (also known as America's Seed Fund) are major sources of early-stage funding for U.S. technology development and commercialization. By pro
The Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs (also known as America's Seed Fund) are major sources of early-stage funding for U.S. technology development and commercialization. NIH SBIR and STTR
Background The Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs (also known as America's Seed Fund) are major sources of early-stage funding for U.S. technology development and commercialization. By pro